Levodopa – history and pharmacology

Parkinson’s as I see it: we invested tons of money to investigate dopamine agonists but couldn’t find any better than dopamine (in the form of l-dopa). The only problem is it’s pharmakokinetics. As for neurotoxicity, I still believe that the small doses used nowadays (as compared to earlier decades or in mice) fare quite well.

So we spend some time reviewing the history of levodopa and the basic pharmacology.

Here are some references:

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