Carbamazepine

We do learn a lot about new inventions such as Zebinix, Trobalt and Lyrica, yet nearly forgot the age old knowledge about the good ole antiepileptic drugs, such as Carbamazepine and Valproate. We recapitulate the history of CBZ’s development, the chemical peculiarities (it is an oligocyclic with all the problems of tricyclic agents), pharmacokinetics and practical aspects. Did you know that most of the pharmacodynamics of CBZ is not really well understood – except perhaps for its Na-channel modifications?

As for literature, I am hard pressed. Most of my knowledge stems from standard textbooks, such as Engel’s textbook.

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